Table 1. Bioassay data regarding the cytotoxicity of Kigelia pinnata stem bark methanolic extract in a panel of human tumor cell lines. The equieffective IC50 concentrations were calculated from the experimental bioassay data using non-linear regression analysis (GraphPad Prizm software).
Treatment |
IC50 (µg/ml) |
|||||||
SKW-3a |
Rehb |
HL-60c |
K-562 d |
DOHH-2e |
HD-MY-Zf |
MCF-7g |
LLh |
|
TME |
15.1 ± 3.4 |
126.0 ± 9.1 |
90.7 ± 4.7 |
186.0 ± 9.2 |
101.0 ± 7.4 |
124.1 ± 8.9 |
11.8 ± 3.8 |
10.2 ± 2.7 |
CF3 |
148.1 ± 7.5 |
n.d. |
n.d. |
n.d. |
n.d. |
n.d. |
n.d. |
n.d. |
CF7 |
150.6 ± 3.4 |
n.d. |
n.d. |
n.d. |
n.d. |
n.d. |
n.d. |
n.d. |
Vincristine* |
0.22 ± 0.1 |
3.3 ± 0.9 |
1.5 ± 0.7 |
4.1 ± 1.4 |
1.2 ± 0.6 |
7.4 ± 1.0 |
3.7 ± 0.6 |
2.2 ± 0.4 |
aT-cell leukemia (a KE-37 derivative), bacute lymphoid leukemia, cacute myeloid leukemia, dchronic myeloid leukemia, enon-Hodgkin lymphoma, fHodgkin lymphoma, gbreast cancer; hLewis lung cell line – murine lung cancer; *positive control.