Table 1. Bioassay data regarding the cytotoxicity of Kigelia pinnata stem bark methanolic extract in a panel of human tumor cell lines. The equieffective IC50 concentrations were calculated from the experimental bioassay data using non-linear regression analysis (GraphPad Prizm software).

Treatment

IC50 (µg/ml)

SKW-3a

Rehb

HL-60c

K-562 d

DOHH-2e

HD-MY-Zf

MCF-7g

LLh

TME

15.1 ± 3.4

126.0 ± 9.1

90.7 ± 4.7

186.0 ± 9.2

101.0 ± 7.4

124.1 ± 8.9

11.8 ± 3.8

10.2 ± 2.7

CF3

148.1 ± 7.5

n.d.

n.d.

n.d.

n.d.

n.d.

n.d.

n.d.

CF7

150.6 ± 3.4

n.d.

n.d.

n.d.

n.d.

n.d.

n.d.

n.d.

Vincristine*

0.22 ± 0.1

3.3 ± 0.9

1.5 ± 0.7

4.1 ± 1.4

1.2 ± 0.6

7.4 ± 1.0

3.7 ± 0.6

2.2 ± 0.4

aT-cell leukemia (a KE-37 derivative), bacute lymphoid leukemia, cacute myeloid leukemia, dchronic myeloid leukemia, enon-Hodgkin lymphoma, fHodgkin lymphoma, gbreast cancer; hLewis lung cell line – murine lung cancer; *positive control.

Momekov et al.Journal of Cancer Therapeutics and Research  2012 1:17DOI : 10.7243/2049-7962-1-17