Table 2. In vivo antineoplastic activity of Kigelia pinnata stem bark methanolic extract against Lewis lung carcinoma, transplanted s.c. in BDF-1 mice as assessed by the increase in life span (ILS %) and tumor growth inhibition (TGI%) endpoints.
|
Experimental group |
MST |
T/C % |
ILS (%) |
Long term survivors1 |
TGI (%) |
|
|
10th Day |
14th Day |
|||||
|
Control (saline ×3) |
20.4 |
N/A |
N/A |
0 |
N/A |
N/A |
|
TME 37.5 mg/kg i.p. (× 3) |
30.2** |
148.0 |
48.0 |
1 |
89.5 |
87.5 |
|
TME 75 mg/kg i.p. (×3) |
34.0** |
166.7 |
66.7 |
2 |
80.7 |
79.8 |
|
TME 100 mg/kg i.p. (×3) |
33.7** |
165.2 |
65.2 |
1 |
81.2 |
88.0 |
1Number of animals that have survived over 60 days; N/A-not applicable; *MST statistically significant (at p≤0.01) vs. the untreated control: p=0.0002 (37.5 mg/kg), p = 0.0044 (75 mg/kg), p = 0.0105 (100 mg/kg) (log-rank test).