Table 2. In vivo antineoplastic activity of Kigelia pinnata stem bark methanolic extract against Lewis lung carcinoma, transplanted s.c. in BDF-1 mice as assessed by the increase in life span (ILS %) and tumor growth inhibition (TGI%) endpoints.

Experimental group

MST

T/C %

ILS (%)

Long term

survivors1

TGI (%)

10th Day

14th Day

Control (saline ×3)

20.4

N/A

N/A

0

N/A

N/A

TME 37.5 mg/kg i.p. (× 3)

30.2**

148.0

48.0

1

89.5

87.5

TME 75 mg/kg i.p. (×3)

34.0**

166.7

66.7

2

80.7

79.8

TME 100 mg/kg i.p. (×3)

33.7**

165.2

65.2

1

81.2

88.0

1Number of animals that have survived over 60 days; N/A-not applicable; *MST statistically significant (at p≤0.01) vs. the untreated control: p=0.0002 (37.5 mg/kg), p = 0.0044 (75 mg/kg), p = 0.0105 (100 mg/kg) (log-rank test).

Momekov et al.Journal of Cancer Therapeutics and Research  2012 1:17DOI : 10.7243/2049-7962-1-17