Table 5: Univariate cox-regression analysis of event free survival in the B- and T-lineage ALL patient group


Variables

B-lineage ALL, n=178

T-lineage ALL, n=32


n

HR

(95% CI)

p

n

HR

(95% CI)

p

Sex

 

 

 

 

 

 

 

 

 Female

  78

1

 

 

8

1

 

 

 Male

100

1.79

1.05–3.06

0.03

24

0.76

0.23–2.99

0.76

Age at diagnosis (years)

 

 

 

 

 

 

 

 

 1 – 9 years

139

1

 

 

25

1

 

 

<1 and  >10 years

39

1.70

0.93-3.11

0.09

7

3.76

1.22 –11.6

0.02

WBC at diagnosis

 

 

 

 

 

 

 

 

< 50.000/ mm3

148

1

 

 

21

1

 

 

> 50.000/ mm3

30

1.18

0.57–2.47

0.65

11

1.90

0.60 –5.95

0.27

Classification*

 

 

 

 

 

 

 

 

 Standard Risk

94

1

 

 

 

 

 

 

 High Risk

84

2.12

1.14–3.97

0.02

32

 

 

 

FAB

 

 

 

 

 

 

 

 

 ALL-L1

145

1

 

 

29

1

 

 

 ALL-L2

33

1.10

0.58–2.10

0.77

3

2.46

0.54 –11.2

0.24

CD10 expression

 

 

 

 

 

 

 

 

 CD10+

138

1

 

 

10

1

 

 

 CD10-

40

1.60

0.90–2.85

0.11

22

3.73

0.82 –17.0

0.09

CD34 expression

 

 

 

 

 

 

 

 

 CD34+

105

1

 

 

7

1

 

 

CD34-

73

1.16

0.68–1.99

0.59

25

0.75

0.21 –2.73

0.66

Combination CD10 and CD34

 

 

 

 

 

 

 

 

 CD10+CD34+

83

1

 

 

1

Numbers are too small to analyze

 CD10+CD34-

55

1.07
1.42
1.91

0.56–2.05

0.85

9

 

 CD10-CD34+

22

0.63-3.23

0.40

6

 CD10-CD34-

18

0.90–4.20

0.11

16

CD10-and CD34-

 

 

 

 

 

 CD10+ and/or CD34+

160

1

 

 

16

1

 

 

 CD10-CD34-

18

1.77

0.86-3.64

0.12

16

3.2

0.96 –10.5

0.06


*Risk Classification based on NCI criteria; HR: Hazard Ratio was calculated with correction for protocol used. One patient was excluded from the analysis in the T-lineage group because this patient was treated with SR protocol.

 

Supriyadi et al.Journal of Cancer Therapeutics and Research  2012 1:20DOI : 10.7243/2049-7962-1-20