Table 6: Univariate cox-regression analysis of overall survival in the B- and T-lineage ALL patient group


Variables

B-lineage ALL, n=178

T-lineage ALL, n=32

n

HR

(95% CI)

p

n

HR

(95% CI)

p

 

Sex

 

 

 

 

 

 

 

 

 Female

78

1

 

 

8

1

 

 

 Male

100

0.53

0.31 – 0.91

0.02

24

1.09

0.35 – 3.42

0.89

Age at diagnosis (years)

 

 

 

 

 

 

 

 

 1 – 9 years

139

1

 

 

25

1

 

 

<1 and  >10 years

39

1.36

0.73 – 2.54

0.33

7

3.56

1.25 – 10.2

0.02

WBC at diagnosis

 

 

 

 

 

 

 

 

< 50.000/ mm3

148

1

 

 

21

1

 

 

> 50.000/ mm3

30

1.08

0.52 – 2.24

0.83

11

2.24

0.78 – 6.42

0.14

Classification*

 

 

 

 

 

 

 

 

 Standard Risk

94

1

 

 

 

 

 

 

 High Risk

84

1.71

0.94 – 3.08

0.08

32

 

 

 

FAB

 

 

 

 

 

 

 

 

 ALL-L1

145

1

 

 

29

1

 

 

 ALL-L2

33

0.86

0.43 – 1.70

0.66

3

1.01

0.13 – 7.71

0.99

CD10 expression

 

 

 

 

 

 

 

 

 CD10+

138

1

 

 

10

1

 

 

 CD10-

40

1.59

0.89 – 2.83

0.12

22

9.91

1.30 – 75.8

0.03

CD34 expression

 

 

 

 

 

 

 

 

 CD34+

105

1

 

 

7

1

 

 

CD34-

73

1.13

0.66 – 1.93

0.66

26

1.41

0.32 – 6.27

0.65

Combination CD10 and CD34

 

 

 

 

 

 

 

 

 CD10+CD34+

83

1

 

 

1

 

 

 

 CD10+CD34-

55

1.02

0.53 – 1.94

0.96

9

Numbers are too small to analyze

 

 CD10-CD34+

22

1.37

0.61 – 3.10

0.45

6

 CD10-CD34-

18

1.88

0.86 – 4.11

0.11

16

 

 

 

CD10- and CD34-

 

 

 

 

 

 

 

 

 CD10+ and/or CD34+

160

1

 

 

16

1

 

 

 CD10-CD34-

18

1.78

0.87 – 3.67

0.12

16

5.89

1.63 –21.3

0.007

Supriyadi et al.Journal of Cancer Therapeutics and Research  2012 1:20DOI : 10.7243/2049-7962-1-20