Table 1 : Genes of SMS-KCNR cells in five categories differentially expressed upon 24-h treatment with PCI-24781, bortezomib and both.


Genes of SMS-KCNR cells differentially expressed upon 24-h treatment with PCI-24781, bortezomib, and both.

      PBmC PmC BmC

Accn # Gene Title/Gene Symbol   F.C. P-value F.C. P-value F.C. P-value

Notch Signaling Pathway

NM_004316 Achaete-scute complex homolog 1 (ASCL1)   -3.002 0.000927 -3.86901 0.00017 -2.19856 0.231699
NM_000389 Cyclin-dependent kinase inhibitor 1A (CDKN1A)   -2.60325 0.002993 -2.71053 1.31E-05 -1.39463 0.478301
NM_005618 Delta-like 1 (DLL1)    3.033902 0.024784  2.877812 0.002491  1.256778 0.790808
NM_005524 Hairy and enhancer of split 1 (HES1)    2.205546 0.001785  2.215463 2.96E-05  1.076456 0.895074
NM_012259 Hairy/enhancer-of-split related with YRPW motif 2 (HEY2)    1.394142 0.081298  1.391811 0.010457 -1.01637 0.998356
NM_000214 Jagged 1 (JAG1)    3.358865 0.030276  4.389256 0.000372  1.447692 0.329478
NM_002226 Jagged 2 (JAG2)    1.297184 0.264245  1.34398 0.062734 -1.01957 0.958371
NM_002228 Jun proto-oncogene (JUN)   -1.40705 0.027099 -1.52671 0.259297 -1.22093 0.564432
NM_032427 Mastermind-like 2 (MAML2)    2.191402 0.005553  2.132724 0.000279  1.070269 0.964675
NM_001200001 Notch-2 (NOTCH2)    47.35651 7.20E-05  59.36702 2.44E-06  2.488318 0.231699
NM_000435 Notch-3 (NOTCH3)    1.720812 0.006448  1.669143 0.00024 -1.00333 1.000000
NM_004557 Notch-4 (NOTCH4)   -2.71993 0.000887 -3.27107 0.000323 -1.69939 0.231699
NM_005378 V-mycmyelocytomatosis viral related oncogene (MYCN)   -1.27879 0.026751 -1.21634 0.017491 -1.18255 0.677238

Oxidative Stress Response

NM_001719 Bone morphogenetic protein 7 (BMP7)    15.579 0.0012  12.9433 1.17E-06  1.6101 0.2891
NM_000088 Collagen type 1, alpha 1 (COL1A1)    5.200 0.0018  4.8706 0.0001  1.2563 0.5705
NM_005794 Dehydrogenase/reductase (SDR family) member 2 (DHRS2)    19.624 0.0001  17.1225 1.42E-05  1.7535 0.2700
NM_005235 V-erb-a erythroblastic leukemia viral oncogene homolog 4 (ERBB4)    21.800 0.0002  19.8785 7.85E-07  2.3799 0.2502
NM_002084 Glutathione peroxidase 3 (plasma) (GPX3)    16.642 0.0003  16.9895 2.13E-06  1.6247 0.3183
NM_001008397 Glutathione peroxidase 8 (putative) (GPX8)    5.060 0.0029  4.5064 0.0001  1.2477 0.5761
NM_0021333 Hemeoxygenase (decycling) 1 (HMOX1)    11.232 7.56E-05  9.145 3.14E-05  1.4662 0.4852
NM_005931 MHC class I polypeptide-related sequence B (MICB)    71.874 6.14E-05  81.096 2.62E-07  2.7817 0.2316
NM_004994 Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (MMP9)    5.252 0.00202  5.198 0.0238  1.2637 0.4267
NM_024420 Phospholipase A2, group IVA (cytosolic, calcium-dependent) (PLA2G4A)    7.690 0.00081  6.700 0.0110  1.2909 0.4072
NM_000962 Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (PTGS1)    12.968 0.00016  9.145 3.14E-05  1.4691 0.2814
NM_000345 Synuclein, alpha (non A4 component of amyloid precursor) (SNCA)    4.230 0.0023  4.111 3.60E-05  1.2162 0.5611
NM_001178040 Syntaxin 3 (STX3)    20.771 9.76E-05  17.330 5.61E-06  1.8778 0.2998

Apoptosis and TNFR

NM_001165 Baculoviral IAP repeat containing 3 (BIRC3)    6.5821 0.000693  6.758683 0.00138  1.4916 0.242024
NM_001226 Caspase 6, apoptosis-related cysteine peptidase (CASP6)    3.4102 0.00104  3.208055 0.000162  1.1764 0.739085
NM_015675 Growth arrest and DNA-damage-inducible, beta (GADD45B)    5.5125 0.002736  5.482137 2.35E-05  1.3944 0.391091
NM_000177 Gelsolin(GSN)    5.3800 0.001  5.109392 1.85E-05  1.5512 0.264134
NM_0021333 Hemeoxygenase (decycling) 1 (HMOX1)    11.2322 7.56E-05  11.45708 5.12E-07  1.7320 0.277403
NM_000594 Tumor necrosis factor (TNF)    7.3495 0.000347  6.408024 8.56E-06  1.8115 0.231699
NM_001270507 Tumor necrosis factor, alpha-induced protein 3 (TNFAIP3)    2.2634 0.005704  2.187222 0.000655  1.4447 0.606515
NM_016639 Tumor necrosis factor receptor superfamily, member 12A (TNFRSF12A)    2.0183 0.007093  1.971959 0.014324  1.3393 0.410985
NM_001164155 Tumor necrosis factor receptor superfamily, member 19 (TNFRSF19)    6.1248 0.000168  6.084076 9.62E-07  1.6015 0.295686
NM_001145645 Tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B)    2.2388 0.003709  1.999324 0.00064  1.4443 0.299862

Cell Cycle Related

NM_001759 G1/S specific cyclin D2 (CCND2)    87.4966 0.000182  95.4013 7.85E-07  1.8244 0.27847
NM_001258 Cyclin-dependent kinase-3 (CDK3)   -1.9674 0.002626 -1.5957 0.036293 -1.3050 0.354757

NF-kB Related

NM_001165412 Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1(NFKB1)   -1.2877 0.165361 -1.1939 0.130896 -1.1483 0.612514
NM_025107 Homo sapiens myc target 1 (MYCT1)    2.0335 0.009183  2.2886 0.000631  1.6837 0.297559
NM_000600 Homo sapiens interleukin 6 (interferon, beta 2) (IL6)   -1.3102 0.056794 -1.3336 0.037262 -1.2640 0.382162
NM_001042533 MYC induced nuclear antigen (MINA)    1.8988 0.015987  1.4745 0.005057  1.6331 0.296344

Up-regulated genes are shown as positive fold change values and down-regulated genes are shown as negative fold change values. Treatment conditions include PCI-24781 and bortezomib minus control (PBmC), PCI-24781 minus control (PmC), and bortezomib minus control (BmC). Fold changes (f.c.) indicate sign fold changes, and p values (p) represent adjusted p values.

Saulnier Sholler et al.Journal of Cancer Therapeutics and Research  2013 2:21DOI : 10.7243/2049-7962-2-21