Table 3 : Reported toxicities with concurrent chemoradiotherapy among group 1 (cisplatin treated patients)
and group II (cisplatin with paclitaxel treated patients).


Variables Group 1 N=25 (%) Group II N=30 (%)

  G1 G2 G3 G4 G1 G2 G3 G4

Early toxicity

Anemia 3 (12%) 5 (20%) 0 (0%) 0 6 (20%) 5 (16.7%) 1 (3.3%) 1 (3.3%)
Leucopenia 4 (16%) 2 (8%) 1 (4%) 0 3 (10%) 2 (6.7%) 1 (3.3%) 0
Thrombocytopenia 1 (4%) 1 (4%) 0 (0%) 0 3 (10%) 2 (6.7%) 0 0
Diarrhea 10 (40%) 3 (12%) 1 (4%) 0 11 (36.7%) 5 (16.6%) 1 (3.3%) 0
Vomiting 12 (48%) 5 (20%) 0 0 13 (43.3%) 7 (23.3%) 2 (6.7%) 0
Proctitis 15 (60%) 3 (12%) 0 0 10 (33.3%) 2 (6.7%) 0 0
Dysuria 8 (32%) 8 (32%) 2 (8%) 0 9 (30%) 8 (26.6%) 3 (10%) 0
Frequency/urgency 6 (24%) 5 (20%) 2 (8%) 1 (4%) 10 (33.3%) 7 (23.3%) 4 (13.3%) 1
Radiation dermatitis 5 (20%) 1 (4%) 0 0 4 (13.3%) 1 (3.3%) 0 0
Increased creatinine 5 (20%) 1 (4%) 0 0 3 (10%0 1 (3.3%) 0 0
Increased bilirubin 0 0 0 0 0 0 0 0
Increased liver enzymes 0 0 0 0 0 0 0 0
Allergy 1 (4%) 0 0 0 2 (6.7%) 0 0 0
Hearing impairment 1 (4%) 0 0 0 1 (3.3%) 0 0 0
Cardiovascular arrhythmia 0 0 0 0 1 (3.3%) 1 (3.3%) 0 0

Late Toxicity

Proctitis 4 (16%) 1 (4%) 0 0 3 (10%) 1 (3.3%) 0 0
Dysuria 6 (24%) 4 (16%) 1 (4%) 0 6 (20%) 3 (10%) 1 (3.3%) 0
Frequency/urgency 15 (60%) 2 (8%) 0 0 9 (30%) 2 (6.7%) 0 0
Increased creatinine 2 (8%) 1 (4%) 0 0 1 (3.3%) 1 (3.3%) 0 0

Essa et al.Journal of Cancer Therapeutics and Research  2016 5:5DOI : 10.7243/2049-7962-5-5