Table 3 : Reported toxicities with concurrent chemoradiotherapy among group 1 (cisplatin treated patients)
and group II (cisplatin with paclitaxel treated patients).
Variables | Group 1 N=25 (%) | Group II N=30 (%) | ||||||
G1 | G2 | G3 | G4 | G1 | G2 | G3 | G4 | |
Early toxicity | ||||||||
Anemia | 3 (12%) | 5 (20%) | 0 (0%) | 0 | 6 (20%) | 5 (16.7%) | 1 (3.3%) | 1 (3.3%) |
Leucopenia | 4 (16%) | 2 (8%) | 1 (4%) | 0 | 3 (10%) | 2 (6.7%) | 1 (3.3%) | 0 |
Thrombocytopenia | 1 (4%) | 1 (4%) | 0 (0%) | 0 | 3 (10%) | 2 (6.7%) | 0 | 0 |
Diarrhea | 10 (40%) | 3 (12%) | 1 (4%) | 0 | 11 (36.7%) | 5 (16.6%) | 1 (3.3%) | 0 |
Vomiting | 12 (48%) | 5 (20%) | 0 | 0 | 13 (43.3%) | 7 (23.3%) | 2 (6.7%) | 0 |
Proctitis | 15 (60%) | 3 (12%) | 0 | 0 | 10 (33.3%) | 2 (6.7%) | 0 | 0 |
Dysuria | 8 (32%) | 8 (32%) | 2 (8%) | 0 | 9 (30%) | 8 (26.6%) | 3 (10%) | 0 |
Frequency/urgency | 6 (24%) | 5 (20%) | 2 (8%) | 1 (4%) | 10 (33.3%) | 7 (23.3%) | 4 (13.3%) | 1 |
Radiation dermatitis | 5 (20%) | 1 (4%) | 0 | 0 | 4 (13.3%) | 1 (3.3%) | 0 | 0 |
Increased creatinine | 5 (20%) | 1 (4%) | 0 | 0 | 3 (10%0 | 1 (3.3%) | 0 | 0 |
Increased bilirubin | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Increased liver enzymes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Allergy | 1 (4%) | 0 | 0 | 0 | 2 (6.7%) | 0 | 0 | 0 |
Hearing impairment | 1 (4%) | 0 | 0 | 0 | 1 (3.3%) | 0 | 0 | 0 |
Cardiovascular arrhythmia | 0 | 0 | 0 | 0 | 1 (3.3%) | 1 (3.3%) | 0 | 0 |
Late Toxicity | ||||||||
Proctitis | 4 (16%) | 1 (4%) | 0 | 0 | 3 (10%) | 1 (3.3%) | 0 | 0 |
Dysuria | 6 (24%) | 4 (16%) | 1 (4%) | 0 | 6 (20%) | 3 (10%) | 1 (3.3%) | 0 |
Frequency/urgency | 15 (60%) | 2 (8%) | 0 | 0 | 9 (30%) | 2 (6.7%) | 0 | 0 |
Increased creatinine | 2 (8%) | 1 (4%) | 0 | 0 | 1 (3.3%) | 1 (3.3%) | 0 | 0 |