Journal of Cancer Therapeutics & Research

Journal of Cancer Therapeutics & Research

ISSN 2049-7962
Case report

Diffuse large b-cell lymphoma with hemophagocytic syndrome in an HIV+ patient treated with CCR5- bone marrow transplant

Elena Vrotsos1*, Crystal Rego2, Mike Cusnir3, Claudio Tuda2 and Vathany Sriganeshan1

*Corresponding author: Elena Vrotsos

1. Mount Sinai Medical Center, Department of Pathology and Laboratory Medicine, Miami Beach, Florida, USA.

Author Affiliations

2. Department of Internal Medicine, Miami Beach, Florida, USA.
3. Department of Hematology and Oncology, Miami Beach, Florida, USA.


Hemophagocytic lymphohistiocytosis (HLH) is a life threatening systemic disease characterized by proliferation of activated lymphocytes/macrophages leading to an exaggerated but ineffective immune response. HLH clinically presents with fever, pancytopenia, splenomegaly and hemophagocytosis in the bone marrow, lymph nodes or liver. HLH has been associated with viral, bacterial, fungal, parasitic infections, and malignancies, particularly T-cell lymphomas, and collagen-associated vascular diseases. We describe a case of an HIV positive patient who presented to the emergency department with fever, cough, diarrhea and abdominal pain. A CT scan revealed diffuse lymphadenopathy. Excisional biopsy of the lymph node showed almost complete effacement of the normal lymph node architecture. The effaced areas were composed of small lymphocytes, medium size cells with features of centroblasts, several immunoblasts and Reed-Sternberg like cells. Increased number of histiocytes with hemophagocytosis was also observed. Diagnosis of EBV positive diffuse large B cell lymphoma was made. In addition, clinical presentation, laboratory results and morphology led to the diagnosis of HLH. This is a unique case describing a wellcontrolled HIV positive patient who developed HLH triggered by reactivation of EBV with diffuse large B cell lymphoma. The patient underwent allogeneic homozygous CCR5-transplant with a possibility of curing his large B cell lymphoma and HIV. He is currently under surveillance for his HIV status and lymphoma.

Keywords: DLBCL, CCR5-transplant, HIV+, EBV+, HLH

ISSN 2049-7962
Volume 3
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