Hormone level  ± SD (95% CI)

Diabetics (n=9)

Controls  (n=5)

baseline

30 minutes

End of study

p-value*

baseline

30 minutes

End of study

p-value*

DHEA (ng/ml)

Placebo

8.5 ± 3.8
(6.0-11.0)

9.5 ± 7.9
(4.3-14.7)

8.7 ± 7.1
(4.1-13.3)

0.80

3.0 ± 1.3
(1.9-4.1)

2.1 ± 1.1
(1.1-3.1)

2.0 ± 0.8
(1.3-2.7)

0.50

DHEA

3.4 ± 1.2
(2.6-4.2)

5.4 ± 3.0
(3.4-7.4)

6.7 ± 4.2
(4.0-9.4)

0.03

2.8 ± 1.5
(1.5-4.1)

9.8 ± 9.5
(1.5-18.1)

8.0 ± 3.9
(4.6-11.4)

0.03

DHEAS (μg/dl)

Placebo

61.3 ± 34.8
(38.6-84.0)

58.8 ± 33.2
(37.1-80.5)

58.7 ± 32.1
(37.7-79.7)

0.90

98.2 ± 105.9
(5.4-191.0)

61.8 ± 43.0
(24.1-99.5)

56.5 ± 45.5
(16.6-96.4)

0.72

DHEA

56.7 ± 27.3
(38.9-74.5)

117.1 ± 90.7
(57.8-176.4)

396.3 ± 97.3
(332.7-459.9)

0.001

90.6 ± 64.7
(33.3-146.7)

180.0 ± 104.4
(88.5-271.5)

447.5 ± 167.3
(300.9-594.1)

0.02

Estradiol (pg/ml)

Placebo

7.2 ± 4.6
(4.2-10.2)

7.1 ± 4.6
(4.1-10.1)

7.5 ± 5.2
(4.1-10.9)

0.98

4.7 ± 6.3
(0-10.2)

2.1 ± 1.1
(1.1-3.1)

4.3 ± 4.1
(0.7-7.9)

0.99

DHEA

6.7 ± 4.3
(3.9-9.5)

7.2 ± 3.9
(4.7-9.8)

20.3 ± 10.1
(13.7-26.9)

0.01

5.0 ± 5.6
(0-9.9)

3.5 ± 2.9
(1.0-6.0)

24.8 ± 26.9
(1.2-48.4)

0.09

Testosterone (ng/dl)

Placebo

15.2 ± 6.8
(10.8-19.6)

14.4 ± 6.4
(10.2-18.6)

14.0 ± 7.0
(9.4-18.6)

0.90

38.2 ± 14.7
(25.3-51.1)

39.0 ± 13.8
(26.9-51.1)

43.6 ± 6.3
(38.1-49.1)

0.60

DHEA

18.0 ± 10.5
(11.1-24.9)

19.3 ± 5.2
(15.9-22.7)

30.0 ± 14.0
(20.9-39.2)

0.01

41.2 ± 20.4
(23.3-59.1)

57.2 ± 30.5
(30.5-83.9)

60.2 ± 22.0
(40.9-79.5)

0.20