Table 3: Summary of pharmacokinetic parameters of glimepiride


Parameter

Glimepiride

Empagliflozin+ glimepiride


AUC0-∞, ng·h/mL

233 (30.9)

218 (34.9)

Cmax, ng/mL

47.4 (31.0)

47.6 (19.7)

tmax, hours*

2.0 (1.0–10.0)

1.5 (1.0–2.5)

t½, hours

3.62 (44.5)

3.84 (60.7)


N=16. Data are mean (%CV) unless otherwise stated.

*Median (range).

AUC0-∞, area under concentration-time curve of glimepiride in plasma over time interval from 0 extrapolated to infinity; Cmax, maximum measured concentration of glimepiride in plasma; tmax, time from dosing to maximum concentration of glimepiride in plasma; t½, terminal half-life of glimepiride in plasma.

Macha et al.Journal of Diabetes Research and Clinical Metabolism  2012 1:14DOI : 10.7243/2050-0866-1-14