Table 2 : Drug therapy, blood glucose, serum creatinine and potassium in a patient with drug-induced hyperglycemia (Patient 3)


Date

Therapy

Glucose (mg/dL)

Scr
(mg/dL)

Serum K (mmol/L)


F

2-hPP

F

2-hPP

F

2-hPP


Dec 2004

HCTZ, SlowK, Amiloride, Amlodipine, MgOxide

104

ND

1.2

ND

3.6

ND

Feb 2005

Same as before

117

ND

1.2

ND

3.9

ND

Oct 2010

Triam+HCTZ (37.5/25) Mon,Wed,Fri

123

ND

1.3

ND

4.1

ND

Sept 8, 2011

Triam+HCTZ Mon, Fri
Amlodipine 10 mg BID, Slow K

123

207

1.3

1.47

4.2

3.4


She was told by her primary physician that she was developing diabetes.  Action: Hold Triam HCTZ, add Aldomet 250 mg TID to control blood pressure, reduce KCl to 20 mEq once daily.


Sept 23, 2011

Hold Triam/HCTZ

114

144

1.2

1.3

4.0

4.0


Actions: 1) Triam + HCTZ discontinued, 2) Bemetamide 0.5 mg PO Mon, Wed, Fri, 3) ↑KCl 20 mEq BID


Nov 2011

Bumetanide

108

118

1.3

1.4

4.1

4.0


<p >ND = Not Done Scr= Serum Creatinine F = Fasting 2-hPP = 2 hour Postprandial

Mandal et al.Journal of Diabetes Research and Clinical Metabolism  2012 1:15DOI : 10.7243/2050-0866-1-15