Figure 1 PPARGC1A DNA methylation and gene expression in muscle, subcutaneous and visceral adipose tissue.(1A) PPARGC1A DNA methylation levels, ** denotes significance between subcutaneous and visceral adipose tissue at P=0.001; # denotes significance between muscle and both subcutaneous and visceral adipose tissues at P(1B) PPARGC1A expression in muscle is significantly higher than subcutaneous and visceral adipose tissue at PObese patients with type 2 diabetes had higher DNA methylation of PPARGC1A in subcutaneous adipose tissue as compared to lean and (1F) obese patients with and without diabetes had lower PPARGC1A expression in subcutaneous adipose tissue as compared with lean individuals. *P=0.01; **P=0.001; # Parbitrary units.

Heilbronn et al.Journal of Diabetes Research and Clinical Metabolism  2012 1:16DOI : 10.7243/2050-0866-1-16