Figure 2 IGF2 DNA methylation and gene expression in muscle, subcutaneous and visceral adipose tissue. (2A) Lower DNA methylation was observed in subcutaneous adipose tissue than visceral adipose tissue and muscle; (2B) Lower IGF2 expression was observed in subcutaneous adipose tissue and visceral adipose tissue versus muscle; (2C-2D) Age was negatively correlated with IGF2 DNA methylation (2C) and positively correlated with IGF2 expression (2D) in muscle; (2E) Patients with type 2 diabetes had significant lower IGF2 DNA methylation in muscle; (2F) IGF2 expression was decreased in obese and obese patients with type 2 diabetes in subcutaneous adipose tissue. *P=0.01; **P=0.001; # P

Heilbronn et al.Journal of Diabetes Research and Clinical Metabolism  2012 1:16DOI : 10.7243/2050-0866-1-16