Cu(II)-ProIAPP1-48 Ratio

0.0

0.5

1.0

2.0

5.0

10.0

ProIAPP1-48 Only       24h

                                           21d

10(  2.6)

42(12.8)

13(2.2)

29(3.3)

  6(5.2)

  8(3.1)

  4(2.0)

  5(1.5)

  0(0.0)

  0(0.0)     

  0(0.0)

  0(0.0)

 

ProIAPP1-48 + Al(III) 24h

                                           21d

46(21.5)

75(23.2)

  7(1.5)

12(0.7)

  5(3.7)

13(3.8)

  4(0.3)

  5(0.5)

  1(0.2)

  5(2.0)

  5(1.1)

  5(0.5)

 

ProIAPP1-48 + Zn(II)  24h

                                           21d

14(  1.9)

36(  3.4)

  8(0.6)

17(8.3)

  6(3.9)

12(5.4)

  1(0.8)

  8(2.8)

  0(0.0)

  1(0.2)

  3(3.7)

  0(0.0)

 

 Table 1. The influence of the ratio of Cu(II) to ProIAPP1-48 on ThT fluorescence of 20 mM ProIAPP1-48 in the absence and presence of 200 mM Al(III) or Zn(II) after 24h or 21 days. Mean and SD are given , n=3.

Exley et al.Journal of Diabetes Research and Clinical Metabolism  2012 1:3DOI : 10.7243/2050-0866-1-3