Figure 3 : Lower rate of change in plasma Apo C-III0 subtype over gestational time in gestational diabetes mellitus cases than controls by mass spectrometry.


(A) Spectra are shown for a single representative GDM patient and age-matched control at gestational age range 16-22 weeks. Apo C-III0 (a-sialylated, 8764 Da), Apo C-III1 (mono-sialylated, 9421 Da), and Apo C-III2 (9712 Da) were readily identifiable as high abundance proteins in the spectra. Arrows denote peaks corresponding to Apo C-III subtype. Quantification of median spectral intensities by SELDI-TOF mass spectrometry for n=4-5 GDM subjects and n=8 age-matched controls at each gestational age for (B) Apo C-III0, (C) Apo C-III1, and (D) Apo C-III2. Error bars denote 95% confidence intervals.
*, p<0.05 by Mann-Whitney U test relative to 4-12 weeks.
CTL, age-matched controls; GDM, gestational diabetes mellitus.

Ippolito et al.Journal of Diabetes Research and Clinical Metabolism  2013 2:22DOI : 10.7243/2050-0866-2-22