Table 2 : Relationship between death or primary endpoint-free survival and patient’s gender, age, HbA1c and GA
measurements.
Global probability values for variable effects are shown in addition to confidence intervals for
comparisons with the reference category.


    Cardiovascular* Cerebrovascular Peripheral vascular

Variable Level N HR 95% CI Pval N HR 95% CI Pval N HR 95% CI Pval

Gender Men 25 1.87 0.92 3.80 0.08 12 1.21 0.50 2.97 0.67 17 1.38 0.63 3.02 0.42
  Women 11 Ref. -- -- -- 8 Ref. -- -- -- 10 Ref. -- -- --
Age <62 3 0.22 0.06 0.79 0.13 1 0.19 0.02 1.53 0.27 8 1.88 0.60 5.86 0.75
(years) 62-66 8 0.67 0.28 1.60 -- 7 1.40 0.48 4.03 -- 6 1.47 0.44 4.86 --
  67-71 11 0.78 0.35 1.73 -- 5 0.79 0.25 2.48 -- 8 1.61 0.52 4.94 --
  72+ 14 Ref. -- -- -- 7 Ref. -- -- -- 5 Ref. -- -- --
HbA1c per unit 36 1.07 0.81 1.41 0.64 20 0.98 0.64 1.49 0.92 27 1.45 1.15 1.84 0.002
(%) <6.6 7 0.63 0.24 1.62 0.80 5 1.30 0.35 4.87 0.66 5 0.47 0.16 1.39 0.22
  6.6-7.0 9 0.84 0.34 2.03 -- 3 0.74 0.16 3.31 -- 3 0.28 0.08 1.05 --
  7.1-7.8 9 0.76 0.31 1.83 -- 8 1.63 0.49 5.44 -- 9 0.76 0.31 1.89 --
  7.9+ 11 Ref. -- -- -- 4 Ref. -- -- -- 10 Ref. -- -- --
GA per unit 36 1.01 0.93 1.10 0.74 20 0.98 0.86 1.11 0.72 27 1.09 1.00 1.18 0.06
(%) <14.1 9 0.65 0.28 1.53 0.32 5 1.17 0.31 4.38 0.83 4 0.42 0.13 1.38 0.26
  14.1-15.8 9 0.80 0.34 1.87 -- 4 1.08 0.27 4.33   4 0.45 0.14 1.48 --
  15.9-18.2 5 0.38 0.14 1.07 -- 7 1.67 0.49 5.72   10 1.04 0.42 2.57 --
  18.3+ 13 Ref. -- -- -- 4 Ref. -- -- -- 9 Ref. -- -- --

        Death Primary composite*

Variable Level N HR 95% CI Pval N HR 95% CI Pval

Gender Men 17 2.85 1.05 7.73 0.04 56 1.46 0.94 2.27 0.09
  Women 5 Ref. -- -- -- 31 Ref. -- -- --
Age <62 1 0.15 0.02 1.16 0.23 11 0.41 0.21 0.81 0.05
(years) 62-66 4 0.54 0.17 1.71 -- 15 0.56 0.31 1.04 --
  67-71 6 0.56 0.21 1.52 -- 26 0.77 0.46 1.28 --
  72+ 11 Ref. -- -- -- 35 Ref. -- -- --
HbA1c Per unit 22 0.60 0.35 1.02 0.06 87 1.22 1.03 1.45 0.02
(%) <6.6 7 3.33 0.69 16.08 0.50 18 0.63 0.35 1.16 0.26
  6.6-7.0 7 2.79 0.57 13.59 -- 17 0.56 0.30 1.05 --
  7.1-7.8 6 2.32 0.47 11.54 -- 26 0.78 0.45 1.35 --
  7.9+ 2 Ref. -- -- -- 26 Ref. -- -- --
GA Per unit 22 0.97 0.85 1.10 0.65 87 1.04 0.98 1.10 0.20
(%) <14.1 6 1.30 0.37 4.63 0.95 19 0.65 0.36 1.17 0.47
  14.1-15.8 6 1.41 0.39 5.05 -- 21 0.78 0.44 1.39 --
  15.9-18.2 6 1.39 0.39 4.93 -- 20 0.70 0.39 1.25 --
  18.3+ 4 Ref. -- -- -- 27 Ref. -- -- --

N: Events, HR: Hazard ratio, CI: Confidence interval, Pval: Probability value. Hazard ratios (HRs) with 95% CIs were calculated treating GA and
Hb1Ac measurements as time-dependent variables in a Cox proportional hazard regression model.
* cardiovascular (first of myocardial infarction, PTCA/stent or CABG).
cerebrovascular (first of apoplectic insult, TIA or carotis-TEA).
peripheral vascular (first of amputation, PTD or bypass-operation).
**first of a primary cardiovascular, cerebrovascular, peripheral vascular event, terminal renal failure, blindness and death.

Hasslacher et al.Journal of Diabetes Research and Clinical Metabolism  2014 3:9DOI : 10.7243/2050-0866-3-9