Table 3 : Relationship between death and renal or ophthalmological event-free survival and
patient’s gender, age, HbA1c and GA measurements. Global probability values for variable
effects are shown in addition to confidence intervals for comparisons with the reference category.


    Renal* Ophthalmological

Variable Level N HR 95% CI Pval N HR 95% CI Pval

Gender Men 84 1.11 0.79 1.54 0.55 45 2.23 1.29 3.86 0.004
  Women 61 Ref. -- -- -- 18 Ref. -- -- --
Age <62 15 0.26 0.15 0.46 <0.0001 6 0.34 0.14 0.86 0.12
(years) 62-66 20 0.32 0.20 0.53 -- 17 0.99 0.52 1.87 --
  67-71 31 0.37 0.25 0.57 -- 17 0.80 0.43 1.50 --
  72+ 79 Ref. -- -- -- 23 Ref.   -- --
HbA1c Per unit 145 1.15 1.00 1.34 0.05 63 1.19 0.98 1.46 0.09
(%) <6.6 23 0.61 0.36 1.02 0.17 14 0.66 0.33 1.31 0.40
  6.6-7.0 36 0.81 0.51 1.29 -- 13 0.57 0.28 1.16 --
  7.1-7.8 50 1.02 0.66 1.57 -- 16 0.67 0.35 1.30 --
  7.9+ 36 Ref. -- -- -- 20 Ref. -- -- --
GA Per unit 145 1.06 1.02 1.10 0.01 63 1.03 0.97 1.10 0.34
(%) <14.1 27 0.51 0.32 0.83 0.06 14 0.69 0.34 1.38 0.70
  14.1-15.8 36 0.71 0.46 1.11 -- 13 0.75 0.37 1.54 --
  15.9-18.2 37 0.76 0.49 1.18 -- 18 0.92 0.48 1.77 --
  18.3+ 45 Ref. -- -- -- 18 Ref. -- -- --

N: Events, HR: Hazard ratio, CI: Confidence interval, Pval: Probability value. Hazard ratios (HRs) with 95% CIs were
calculated treating GA and Hb1Ac measurements as time-dependent variables in a Cox proportional hazard
regression model.
*renal (first of death by any cause, terminal renal failure, reduction of eGFR to less than 60 ml/min or onset of
macroalbuminuria, i.e. an albumin/creatinine ratio over 300 mg/g in female patients and over 200 mg/g in male
patients).
ophthalmological (first of death by any cause, blindness, diagnosis of persistent retinopathy or retinopathy
progression).

Hasslacher et al.Journal of Diabetes Research and Clinical Metabolism  2014 3:9DOI : 10.7243/2050-0866-3-9