2. Nuclear Medicine, Hôpital Haut-Lévêque, Avenue de Magellan, 33600 Pessac, France.
Objectives: Are the adult patients hospitalized for new-onset diabetes changing ?
Research Design and Methods: The patients were identified in the registry of admissions of the Nutrition-Diabetology unit of the Universitary Hospital of Bordeaux, France, for the years 1996-1997 and 2008-2009, and compared by ANOVA and Chi-2, before and after being categorized according to the presence of antiGAD antibodies.
Results: One hundred and fifty-three patients (106 men, 51 antiGAD+) were admitted: 61 during 1996-1997 and 92 during 2008-2009, with similar clinical presentations: -6.7±5.8 kg weight loss, plasma glucose 20±16 mmol/L, HbA1C 11.9±2.5%. The 2008-2009 patients were younger (41±16 yrs vs 1996-1997: 47±18, p<0.05), due to younger antiGAD+ patients (28±9 yrs vs 1996-1997: 38±17, p<0.05). The antiGAD- 2008-2009 patients were heavier (78.1±24.1 kg vs 1996-1997: 66.1±12.1 p<0.05), and tended to more frequently consume sugar-sweetened beverages (43% vs 1996-1997: 22%, p=0.059). The treatment had similar effects on both periods: capillary glucose at discharge 138±38 mg/dL, HbA1C 7.2±1.7% four months later, but the hospitalizations were 25% shorter on 2008- 2009 (7.5±2.7 days vs 1996-1997: 9.9±5.4, p<0.005). Discharges without insulin were less frequent on 2008-2009 (20% vs 1996-1997: 36%, p<0.05), concerning very heavier patients (93.2±28.8 kg vs 76.9±18.0, p<0.05).
Conclusions: Fifty percent more adult patients were hospitalized for inaugural diabetes during 2008-2009. The proportion of antiGAD+ patients did not change but they were 10yrs younger, whereas the antiGAD- patients were 12kg heavier. The duration of hospitalization was reduced by -25%, with similar HbA1C 4 months later, but less patients were discharged without insulin.
Keywords: diabetes, onset, adult, obesity, antiGAD