Journal of Diabetes Research & Clinical Metabolism

Journal of Diabetes Research & Clinical

ISSN 2050-0866
Short report

Effect of intermittent high intensity exercise on counter-regulatory hormones in type 1 diabetes glargine/glulisine users

Marie-Christine Dubé1,2, Carole Lavoie3 and S. John Weisnagel1,2*

*Correspondence: S. John Weisnagel

1. Diabetes Research Unit, Université Laval Medical Center, Québec City, QC, Canada.

Author Affiliations

2. Molecular Endocrinology and Genomics, Université Laval Medical Center, Québec City, QC, Canada.

3. Department of Physical Activity Sciences, Université du Québec à Trois-Rivières, QC, Canada.


Background: Brief intense sprint intervals during moderate intensity exercise prevent hypoglycemia in type 1 diabetic participants. We tested the hypothesis that this exercise modality would increase counter-regulatory hormones and limit BG decrease in glargine/glulisine insulin analogs users.

Findings: Participants performed, in a repeated measures, random-ordered design, 60 minutes of moderate intensity exercise at 50% VO2peak in the following conditions: ingestion of 0 g of glucose pre-exercise, 30 g of glucose pre-exercise, or 0 g of glucose preexercise, but interspersed with brief high intensity intervals every 2 minutes. Intermittent brief high intensity exercise significantly increased levels of norepinephrine at mid-exercise (from 3.2±1.0 to 7.8±3.2 nmol/l) and cortisol from mid-exercise (from 330±159 to 606±285 nmol/l) to even after exercise (692±334 nmol/l) compared to other conditions.

Conclusions: Our results suggest that an intermittent high intensity exercise raised counter-regulatory hormones which may contribute to the prevention of exercise-induced hypoglycaemia in participants with type 1 diabetes using glargine/glulisine. Such exercise regimen can be an alternative to prevent exercise-induced hypoglycemia in glargine/glulisine users as seen in other insulin combinations.

Keywords: Hypoglycemia, glulisine, glargine, counter-regulatory hormones, intermittent high intensity exercise, strategies, type 1 diabetes

ISSN 2050-0866
Volume 3
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