Figure. 1 Netsplitter interface for selecting external metabolites Matrix display of network connectivity structure, where disjoint blocks (indicated by a blue background) correspond to subnets already separated by the current set of external metabolites. Each row or column represents an internal metabolite. Within each block, dark grey shades indicate the cores of further partially separated blocks, and lighter grey shades identify metabolites that link them. Candidate rows and columns proposed by the program for reclassifying as externals, are highlighted in orange and listed explicitly on the right for approval by the user. Tab labels at the top
give access to detailed blockwise listings of metabolite categories.

(a) Demonstration example for a small network ( flavonoid metabolism, 117 reactions
x 137 metabolites)

(b) Genome-scale network for Mus musculus [29] (2037
reactions x 2179 metabolites).

Wynand S Verwoerd Journal of Molecular Engineering and Systems Biology  2012 1:2DOI : 10.7243/2050-1412-1-2