Figure 2 : A cross section of aortic arch from hypercholesterolemic rabbit represented atherosclerosis progression (x40).

A: normal arterial appearance as shown for the normal diet control group (group I), B: initial atherosclerotic lesion characterized by lipid laden macrophage  (foam cells), commonly seen in aliskiren treated group (group III), C: intermediate atherosclerotic lesion characterized by extracellular lipid pool. D: Advance atherosclerotic lesion characterized by core of extracellular lipid and E: complicated atherosclerotic lesion characterized by hemorrhagic thrombus. Both D&E were seen in the atherogenic group (group II).

A Al-Aubaidy et al.Journal of Pharmaceutical Technology and Drug Research  2013 2:11DOI : 10.7243/2050-120X-2-11