Table 3 : Half-Factorial experimental design with 5 variables,
2 vevels and 1 center point.


Experiment # X7 X6 X8 X3 X4

13 + + +
14 + + +
15 + + +
16 +
17 +
18 + + +
19 + + +
20 + + +
21 + + +
22 +
23 + + +
24 + + +
25 +
26 + + +
27 0 0 0 0 0
28 +
29 + + + + +

*Presence of excipients is identified by “+”.
Absence of excipients is identified by “−”.
Intermediate level between presence and absence of
excipients is identified by “0”.

Maltais et al.Journal of Pharmaceutical Technology and Drug Research  2015 4:2DOI : 10.7243/2050-120X-4-2