Table 4 : Reduced and full factorial experimental designs with attempted excipient levels.


    Excipient Levels (mg/tablet)

Type of Design Experiment # Hydroxypropyl cellulose Hydroxyethyl cellulose Lactose Croscarmellose sodium

Reduced Design
with 2 Variables
30 15 *Present, but not used as a
variable in this design
15 Present, but not used as
a variable in this design
31 5 35
32 15 25
33 5 20

Full Design with
2 Variables
34 20 5 Present, but not used as
a variable in this design
35 20 10

Reduced Design
with
2 Variables
36 5 15 §Present, but not used as
a variable in this design
37 10 10

Full Design with
2 Variables
38 ǁPresent, but not used as
a variable in this design
20 13.5
39 20 27
40 30 13.5
41 30 27

*Hydroxyethyl cellulosewasused in experiment #33 only,at 15 mg/tablet, in order to acquire additional information onits possible effect on tablet appearance enhancement.
Croscarmellose sodium was used at the same level (5.1 mg/tablet)in experiments #30 to #33.
Lactose was used at 10 mg/tablet and 15 mg/tablet in experiments #34 and #35, respectively, in order to equilibrate the tablet weight between experiments, whereas
croscarmellose sodium was used at the same level (8.5 mg/tablet) in both experiments #34 and #35.
§Lactose and croscarmellose sodium were used in 20 mg/tablet and 13.5 mg/tabletin experiments #36 and #37, respectively.
ǁHydroxypropyl cellulose and hydroxyethyl cellulose were each used at the same levels (10 mg/tablet) in experiments #38 to 41.

Maltais et al.Journal of Pharmaceutical Technology and Drug Research  2015 4:2DOI : 10.7243/2050-120X-4-2