Table 5 : Optimal levels of selected excipients in the new formulation.

(Active ingredient)
Selected excipient Role of excipient Affected response Optimal level

215 mg/tablet Sorbitol Hardness enhancer Hardness and Friability 5 mg/tablet
Hydroxypropyl cellulose Binder 10 mg/tablet
Lactose Disintegration enhancer Disintegration Time 30 mg/tablet
Croscarmellose sodium Disintegrant 13.5 mg/tablet
Hydroxyethyl cellulose Binder and Appearance Enhancer Tablet Appearance 10 mg/tablet

Maltais et al.Journal of Pharmaceutical Technology and Drug Research  2015 4:2DOI : 10.7243/2050-120X-4-2