Table 6 : Comparison of the current(Left) and new (Right) senna tablet formulations.

Parameters Current Senna Formulation New Senna Formulation

Manufacturing Process Wet Granulation Direct Compression

Active Ingredient Senna Senna

Excipients Microcrystalline Cellulose,
Corn Starch, Magnesium Stearate
Hydroxypropyl cellulose,
Hydroxyethyl cellulose, Lactose, Sorbitol,
Croscarmellose sodium, Silicone dioxide (0.5%),
Magnesium stearate (1.5%)

Tablet Assay 90-110% 108.5%
Tablet Moisture ≤6% 4.79%

Tablet Hardness Conforms to:
Average: [3.5-7.0] Kp
Individuals: [3.0-8.0] Kp
Average: 4.6 Kp
Individuals: [3.1-5.6] Kp

Tablet Friability ≤1% 0.33%
Tablet Disintegration Time ≤45 min.
(Typically 10 to 15 minutes)
31 min.

Tablet Appearance Round Brown Biconvex Round Brown Biconvex
Average Tablet Weight Typically 260 mg 289.4 mg

Tablet Image
(Left: Current Senna Tablet)
(Right: New Senna Tablet)

Maltais et al.Journal of Pharmaceutical Technology and Drug Research  2015 4:2DOI : 10.7243/2050-120X-4-2