Table 2 : Arithmetic means [±standard error] of pharmacodynamic parameters obtained in 12 healthy subjects
(4 men and 8 women) after a single oral dose of 40 mg of furosemide from Test (T) or Reference (R) formulations.


  TMAX (h)a ERMAX (mmol/h) E0-12 (mmol)

  T R T R T R

Male            
Chloride 1.33 [0.83-1.83] 1.00 [0.50-1.17] 114 [17] 157 [18] 224 [18] 278[35]
Sodium 1.33 [0.83-1.83] 1.00 [0.50-1.17] 107 [18] 149 [15] 214 [31] 262 [30]
Potassium 1.50 [0.83-1.83] 1.17 [0.50-1.50] 12 [1.3] 14 [1.9] 47 [2.6] 50 [2.8]
Urine 1.33 [0.83-1.83] 1.00 [0.50-1.17] 15.7 [2.8]b 21.0 [2.3]b 2056 [251]c 2432 [120]c

Female            
Chloride 1.00 [0.50-2.50] 0.83 [0.83-1.83] 120 [9.2] 116 [6.9] 213 [19] 198 [20]
Sodium 1.00 [0.50-2.50] 0.83 [0.83-1.83] 113 [10] 110 [7.7] 199 [18] 191 [20]
Potassium 1.50 [0.83-2.50] 1.50 [0.83-1.83] 13 [0.7] 13 [1.0] 44 [2.6] 44 [3.4]
Urine 1.00 [0.50-1.50] 0.83 [0.83-1.83] 17.0 [1.1]b 17.6 [1.2]b 2227 [179]c 2207 [208]c

Total            
Chloride 1.17 [0.50-2.50] 0.83 [0.50-1.83] 118 [7.9] 130 [9.2] 216 [15] 225 [20]
Sodium 1.17 [0.50-2.50] 0.83 [0.50-1.83] 111 [8.6] 123 [8.7] 204 [15] 215 [19]
Potassium 1.33 [0.83-2.50] 1.17 [0.50-1.83] 13 [0.6] 13 [0.9] 45 [1.9] 46 [2.6]
Urine 1.17 [0.50-1.83] 0.83 [0.05-1.83] 16.6 [1.1]b 18.8 [1.2]b 2170 [141]c 2282 [144]c

aMedian and range instead of mean and standard error for TMAX
bExcretion rate of urine (mL/min); cVolume of urine (mL)

Fagiolino et al.Journal of Pharmaceutical Technology and Drug Research  2016 5:2DOI : 10.7243/2050-120X-5-2