Journal of Regenerative Medicine & Tissue Engineering

Journal of Regenerative Medicine & Tissue Engineering

ISSN 2050-1218
Original Research

Hydrodynamics and bioprocess considerations in designing bioreactors for cardiac tissue engineering

Ailing Teo1,2, Athanasios Mantalaris2, Mayasari Lim1*

*Corresponding author: Mayasari Lim

1. School of Chemical & Biomedical Engineering, Nanyang Technological University, Nanyang Drive, Singapore.

Author Affiliations

2. Department of Chemical Engineering, Imperial College London, South Kensington Campus, Exhibition Road, London, UK.


One of the most attractive fields in regenerative medicine and tissue engineering is cardiac cell regeneration due to the limited capacity of the heart muscle to regenerate itself. Recent advances in the field of stem cell bioprocess technology and biomaterials have accelerated progress in creating three-dimensional (3D) cardiac engineered tissues in vitro. Control of bulk and microscopic transport efficiency, which is determined by the choice of the bioreactor design and substrate material, poses direct influence on cell viability, proliferation and differentiation in vitro. This paper provides a critical review on the hydrodynamic considerations with respect to design aspects of the bioreactor and selection of substrate material for 3D cardiac tissue engineering.

Keywords: shear stress, flow dynamics, porosity, topography, stiffness, proliferation, differentiation

ISSN 2050-1218
Volume 1
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