Table 2 : Pros and cons of the "Thrifty Gene Hypothesis".

Pros Cons

Human history of famine Imprecise/vague estimates of mortality.
Food deprivation --
Cannibalism Hunter-gathering communities were less susceptible to famine than after the agriculture development.
High mortality rates --
Gene mutation (thrifty gene) creating a survival advantage (fat storage) Infectious diseases, rather than starvation, are the main cause of mortality during famine period.
Theoretically, an obese person lives longer in condition of complete absence of food compared to a lean person Low prevalence of obesity between famines.

Gibert et al.Journal of Medical Disorders  2013 1:4DOI : 10.7243/2053-3659-1-4