2. Dept of surgery, Byramjee Jeejeebhoy (BJ) Medical college, Near. Pune railway station, bjmedical road, Pune,India.
3. Department of Computer Science and IT, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad (Maharashtra), India.
Background: Interaction of microwaves with water molecules has been found to be a very sensitive probe of molecular surroundings. It has been shown that the dielectric properties of saliva extracted from the mouth contain information about the health of tissues present in the mouth. Based on these principles, the present paper reports instruments used in vivo to derive information related to dielectric properties of saliva in a subject's mouth.
Methods: The instrument consisted of a pulse generator, transmission line and probe. The probe was made from a microstrip line that could be placed easily in the subject's mouth. The reflected pulses were acquired by placing the probe in the mouth and also again outside the mouth. The difference in reflected pulses in and outside the mouth provided information about impedance of saliva. Pulse features were extracted to determine the status of oral cancer.
Results: The experiments have been carried out on 125 subjects with healthy condition and with different stages of oral cancer. The results have been classified into five groups. The features extracted from the data have been classified using Linear Discriminant Analysis (LDA) using the Matlab toolbox. The clustering patterns for different cases were found to be distinct.
Conclusion: The technique may be used to suggest the presence of oral cancer. It was also concluded that more cases under different backgrounds need to be studied before it will be possible to adopt the equipment in actual practice.
Keywords: Microwaves, time domain reflectometry, saliva, oral squamous cell carcinoma, tobacco, linear discriminant analysis