2. Neuroscience Research Group, University of Antioquia, Medellín, Colombia.
3. Genome Discovery Unit, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.
4. Research Group in Statistics, Department of Statistics, National University of Colombia at Medellín, Medellín, Colombia.
5. Genome Diversity and Health Group, Department of Genome Biology, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.
Recently, we presented a new method of pooling/resampling genome-wide association study (prGWAS) that uncovered new and known loci associated to Alzheimer's disease. In here, we contrast this method with the Welcome Trust Case Control Consortium (WTCCC) data, a well-known GWAS on seven human complex diseases. Our results suggest that prGWAS can be considered an efficient, specific, and accurate alternative to the conventional GWAS approach at a fraction of the genotyping cost, and provide insights into other potential applications such as next generation sequencing.
Keywords: Case/control data, GWAS, DNA pooling, prGWAS, subsampling