Table 2 : Hazard rate ratios of cardiovascular diseases according to the presence
of renal calculi in the EPIC-Potsdam study.


        Renal calculi

  No
(n=21,845)
Yes
(n=2,645)
   

Person-years 177,658 21,388 -- --

Cardiovascular diseases

Cases n (%) 416 (1.90) 78 (2.95) -- --

  HR HR 95% CI p value

Model 1* 1 1.03 0.80, 1.31 0.83
Model 2 1 1.05 0.82, 1.34 0.73

Fatal CVD

Cases n (%) 38 (0.18) 11 (0.43) -- --
Model 1* 1 1.70 0.86, 3.38 0.13
Model 2 1 1.66 0.83, 3.31 0.15

Myocardial infarction

Cases n (%) 209 (0.96) 42 (1.59) -- --

  HR HR 95% CI p value

Model 1* 1 1.08 0.77, 1.51 0.66
Model 2 1 1.13 0.80, 1.58 0.49

Fatal myocardial infarction

Cases n (%) 16 (0.07) 6 (0.23) -- --
Model 1* 1 2.32 0.89, 6.09 0.09
Model 2 1 2.33 0.88, 6.13 0.09

Stroke

Cases n (%) 207 (0.95) 36 (1.36) -- --

  HR HR 95% CI p value

Model 1* 1 0.98 0.68, 1.40 0.90
Model 2 1 0.97 0.68, 1.39 0.86

Fatal stroke        

Cases n (%) 22 (0.10) 5 (0.19) -- --
Model 1* 1 1.28 0.47, 3.44 0.63
Model 2 1 1.24 0.46, 3.33 0.68

Abbreviations: CI: confidence interval, EPIC: European Investigation into Cancer and Nutrition,
HR: hazard rate ratio, *Adjusted for age and sex.
Like model 1, further adjusted for education (vocational training or less(reference), technical
school, university degree), physical activity (continuous in hours/week), smoking (never
(reference), past, current <20 cigarettes/d, current ≥20 cigarettes/d), alcohol intake (men: 0, ≤12g/d
(reference), >12 - ≤24g/d, >24g/d, women: 0, ≤6g/d (reference), >6 - ≤12g/d, >12g/d ),
BMI (continuously), waist circumference (continuously), prevalent hypertension and prevalent
diabetes (present/absent).

Wirth et al.Clinical Nephrology and Urology Science  2014 1:3DOI : 10.7243/2054-7161-1-3