Table 1 : Examples of common DNA repair aberrations in cancer.


Protein Pathway Cancer type

BRCA1 HRR Breast and ovarian cancer
MGMT Direct repair Glioblastoma
MLH1 and MSH2 MMR HNPCC
Artemis NHEJ Lymphoma
ERCC1 NER SCCHN

Peters et al.Oncology Discovery  2014 2:3DOI : 10.7243/2052-6199-2-3