Table 2 : Examples of methylated DNA repair genes in cancer.


Repair pathway Gene Cancer type Reference

Base excision repair MBD4 Multiple myeloma
Colorectal cancer
Ovarian cancer
[98]
[99]
[99]
TDG Multiple myeloma [98]
OGG1 Papillary thyroid cancer [100]

Nucleotide excision
repair
XPC Bladder cancer
Lung cancer
[101]
[102]
RAD23A Multiple myeloma [103]
ERCC1 Glioma [93,94]

Mismatch repair MLH1 Sporadic colorectal cancer
Colon cancer
Sporadic endometrial cancer
Gastric cancer
Ovarian cancer
Acute myeloid leukemia
Non-small cell lung cancer
Head and neck squamous cell carcinoma
Oral squamous cell carcinoma
[104]
[105]
[106]
[107,108]
[109,110]
[111]
[112]
[113,114]
[115]
MSH2 Non-small cell lung cancer
Oral squamous cell carcinoma
Ovarian cancer
[112]
[115]
[110]

Direct repair MGMT Colon cancer
Glioblastoma
Gastric carcinoma
Non-small cell lung cancer
Small cell lung cancer
Head and neck squamous cell carcinoma
Cervical cancer
[116]
[53]
[117]
[118]
[54]
[119]
[120]

Non-homologous
end joining
XRCC5 Non-small cell lung cancer [121]

Homologous recombination BRCA1 Breast cancer
Non-small cell lung cancer
Ovarian cancer
Uterine leiomyosarcoma
Gastric cancer
Bladder cancer
[75]
[121]
[122]
[123]
[124]
[125]

Peters et al.Oncology Discovery  2014 2:3DOI : 10.7243/2052-6199-2-3