Table 4 : DNA repair gene methylation and therapy resistances in cancers.


DNA repair gene methylation Effect Chemotherapeutic
agent
Cancer type Reference

MGMT Sensitizing TMZ Glioma
Small cell lung cancer
[50]
[54]
BCNU Glioma
Breast cancer
[49,53]
[126]
CCNU Glioma [49]
Streptozotocin Glioma [50]
Dacarbazine Colorectal cancer [127]

BRCA1 Sensitizing PARP inhibitors Breast cancer [74,75]
Cisplatin Breast cancer
Ovarian cancer
[77]
[77]
Carboplatin Breast cancer
Ovarian cancer
[77]
[77]

MLH1 Resistance promoting 5-FU Colorectal cancer [80]
TMZ Ovarian cancer [81]
Cisplatin Ovarian cancer [82,128]
Carboplatin Ovarian cancer [82,89]
Oxaliplatin Gastric cancer [84]

ERCC1 Sensitizing Cisplatin Glioma [93]
Radiotherapy Glioma [94]

Peters et al.Oncology Discovery  2014 2:3DOI : 10.7243/2052-6199-2-3