Abstract

Therapy resistance remains a challenge in the treatment for osteosarcoma (OS). By studying therapy resistance and gaining biological understanding of resistance in OS, novel treatment targets to sensitise OS could potentially be discovered. The aim of this review is to give an overview of the mechanisms of resistance employed by OS cells after cytotoxic treatment, the key molecules involved in therapy resistance combined with the (pre)clinical research performed on this subject in a search to discover means to overcome therapy resistance and thus improve treatment efficacy for OS.

Keywords: Osteosarcoma, drug resistance, therapy, novel treatment