Table 1 : Enantioselective reaction of 7a.


Entry RI LA (eq) Product (% yield)b Ee (%)c

1 i-PrI 1.0 8a (87) 80
2 i-PrI 0.5 8a (85) 81
3 i-PrI 0.3 8a (82) 81
4 c-Hexyl I 1.0 8b (82) 81
5 t-BuI 1.0 8c (85) 92

aReactions were carried out using RI (30 eq) and 1 M Et3B in
hexane (2.5 eq) at -78 °C.
bIsolated yields.
cEnantioselectivities were determined by HPLC analysis.

Miyabe et al.Universal Organic Chemistry  2014 2:1DOI : 10.7243/2053-7670-2-1