Table 1 : Enantioselective reaction of 7a.
Entry | RI | LA (eq) | Product (% yield)b | Ee (%)c |
1 | i-PrI | 1.0 | 8a (87) | 80 |
2 | i-PrI | 0.5 | 8a (85) | 81 |
3 | i-PrI | 0.3 | 8a (82) | 81 |
4 | c-Hexyl I | 1.0 | 8b (82) | 81 |
5 | t-BuI | 1.0 | 8c (85) | 92 |
aReactions were carried out using RI (30 eq) and 1 M Et3B in
hexane (2.5 eq) at -78 °C.
bIsolated yields.
cEnantioselectivities were determined by HPLC analysis.