Trends in Vector Research and Parasitology

Trends in Vector Research and Parasitology

ISSN 2054-9881
Original Research

Antifilarial activity of Butea monosperma L. leaves extracts against Setaria cervi

Madhuri Deshmukh, Keertisheel N. Sahare, Rakesh Kumar Patidar, Bharti Mahajan and Vinod Singh*

*Correspondence: Vinod Singh vsingh3@rediffmail.com

Author Affiliations

Department of Microbiology, Barkatullah University, Bhopal, Madhya Pradesh, India.

Abstract

Background: Usage of herbal drugs in traditional medicine is quite well known but largely empirical. Hence the present study was designed to screen the in vitro antifilarial effect of Butea monosperma L. plant leaves against Setaria cervi.

Methods: Antifilarial activity of Methanol/Hexane-ethanol extracts of Butea monosperma L. (leaves) and Ciprofloxacin was explored against adult of Setaria cervi after incubation for 24 hrs with concentration range of 0.25 to 20 mg/ml for possible antifilarial effect by comparing with suitable control, in terms of motility inhibition assay and MTT reduction assay.

Results: Butea monosperma L. plant leaves showed significant antifillarial activity against adult as compared to controls whereas activity demonstrated by Ciprofloxacin was comparatively less significant. Inhibitory concentrations (IC50) for the plant extracts with significant antifilarial activity against Setaria cervi adult in vitro system have been derived to be 1.25, 3.6 and 7.5 mg/ml Methanol, Hexane-ethanol extracts and Ciprofloxacin respectively.

Conclusion: The present research investigation proved to be an additional frame in recording the plant extract's antifilarial activity. Methanol and Hexane-ethanol extracts of Butea monosperma L. plant leaves which shown significant antifilarial activity. The present research data highlights the importance of further depth research in this area.

Keywords: Filariasis, in vitro, Drug discovery, Setaria cervi, Butea monosperma L

ISSN 2054-9881
Volume 1
Abstract Download