Pathology Discovery

Pathology Discovery

ISSN 2052-7896
Case report

ALK positive diffuse large B-cell lymphoma, lymphoplasmablastic differentiation

Dlal Nemenqani, Enaam Junainah*, Saeed Al-Amoudi, Jamal Junainah, Amany Mamdouh, Huda Bajunaid and Abdulelah Saber

*Correspondence: Enaam Junainah

Author Affiliations

Departments of Pathology, King Abdulazis Specialist Hospital, Taief, Saudi Arabia.


We report detailed clinical and pathologic features of cases of anaplastic lymphoma kinase-positive diffuse large B-cell lymphoma (ALK-DLBCL), a rare entity with only 33 currently reported cases. This reported case. Biopsies from adult male patients aged, 44 years (three lymph nodes And one skin lesion) the lymph node exhibited immunoblastic/plasmablastic morphology. By immunohistochemistry and they expressed cytoplasmic ALK-1, CD138, VS38 (3/3), monoclonal cytoplasmic light Chain, CD45, CD19, CD79 and were negative for CD3, CD30, CD20 and EMA. Showed rare CD43 (.) reactivity.

Keywords: ALK positive, difuuse large B-cell lymphoma, lymphoplasmoblastic pattern, anaplastic lymphoma

ISSN 2052-7896
Volume 1
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