Pathology Discovery

Pathology Discovery

ISSN 2052-7896
Case report

Primary malignant melanoma of the female urethra: a rare case of cytological observation

Naomi Kawaguchi1, Kyoko Nambu1, Asuka Sekiya1, Toshimasa Sakakima2, Masashi Matsuyama1, Fumimasa Etori1, Hisao Komeda3, Kuniaki Hirai1, Naoki Watanabe1, Takafumi Naiki2, Tetsuya Yamada4 and Takuji Tanaka1,5*

*Correspondence: Takuji Tanaka takutt@gmhosp.gifu.gifu.jp

1. Department of Diagnostic Pathology (DDP) and Research Center of Diagnostic Pathology (RC-DiP), Gifu Municipal Hospital, 7-1 Kashima-cho, Gifu City, Japan.

Author Affiliations

2. Department of Central Laboratory, Gifu Municipal Hospital, 7-1 Kashima-cho, Gifu City, Japan.

3. Department of Urology, Gifu Municipal Hospital, 7-1 Kashima-cho, Gifu City, Japan.

4. Department of Diagnostic Pathology, Kizawa Memorial Hospital, 590 Shimofurui, Furui-machi, Minokamo City, Japan.

5. Department of Tumor Pathology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu City, Japan.

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Abstract

We herein report a rare case of primary malignant urethral melanoma developed in an elderly Japanese patient with hypertension, diabetes and hyperlipidemia. An 80-year-old female presented at our hospital with a history of urodynia and perineal pain lasting for several months. Cystoscopy revealed cystitis and urethritis with erosion. At that time, urinary cytology was negative for malignancy, although melanophages were observed. Four months later, lower abdominal computed tomography and magnetic resonance imaging indicated urethral tumors. Urinary cytology subsequently detected malignant melanoma, and a biopsy of the urethra confirmed malignancy. Although inguinal lymph node metastasis was found 16 months postoperatively, the patient has remained free of disease for more than six years after surgery and chemotherapy.

Keywords: Malignant melanoma, urethra, female, urinary cytology, immunohistochemistry

ISSN 2052-7896
Volume 2
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