Pathology Discovery

Pathology Discovery

ISSN 2052-7896
Original Research

Effects of β-glucans on benign hyperplasia of prostate

Vetvicka Vaclav1*, Richter Josef2, Kral Vlastimil2, Pohorska Jitka2, Stiborova Ivana2, Rajnohova Dobiasova Lucie2, Vincikova Andrea2 and Jilek Dalibor2

*Correspondence: Vetvicka Vaclav

1. Department of Pathology,  University of Louisville, Louisville, KY, USA.

Author Affiliations

2. Institute of Public Health in Ústí nad Labem, Czech Republic.


Background: The stimulation of immune reactions represents a well-established effect of glucan. However, very little is known about the effects on prostate. In this report, we focused on patients with benign hyperplasia of prostate and evaluated the effects of glucan supplementation.

Methods: We measured the level of CRP, levels of total (tPSA) and free PSA (fPSA) and number of NK cells.

Results: We found positive effects on both NK cell numbers and on the PSA index, suggesting positive effects of glucan supplementation. Our data are further supported by a case report.

Conclusions: Our study offers preliminary results supporting the hypothesis that oral administration of glucan has positive effects in patients suffering from benign prostate hyperplasia. Our conclusion is supported by the case report showing significant effects with longer supplementation and higher dose.

Keywords: Glucan, supplement, prostate hyperplasia, NK cells, CRP, PSA

ISSN 2052-7896
Volume 2
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