Abstract

Background: Glucans are known for their effects on anti-infection immunity. However, the individual papers always focused on one glucan, and no attempts were ever made to use one particular glucan in numerous infection.

Methods: In our study, we use yeast-derived glucan #300, previously shown to ameliorate the effects of two different infections, to evaluate its anti-infection effects on mouse model of Mycobacteria bovis, Aeromonas hydrophila and Escherichia coli infection. Effects of supplementation was evaluated after 14 days of oral suppelentation with glucan.

Results: In case of E. coli infection, we found glucan treatment achieved strong improvements in lowering numbers of bacterial in the spleen. Similar effects were found in the number of specific antibodies and survival. Similarly, glucan supplementation caused significant reduction of tissue bacterial load in Aeromonas infection and the spleen of Mycobacterium bovis infected mice.

Conclusions: Our results clearly demonstrated that once the glucan significantly improved anti-infection reaction of mice.

Keywords: Glucan, infection, immunity, survival, supplementation