Stem Cell Biology and Research

Stem Cell Biology and Research

ISSN 2054-717X
Original Research

The cell system of Giardia lamblia in the light of the protist stem cell biology

Vladimir F. Niculescu

Correspondence: Vladimir F. Niculescu

Author Affiliations

Kirschenweg 1, 86420 Diedorf, Germany.


Cell differentiation in Entamoeba and Giardia exhibit a great deal of similarity. Unfortunately, both protists were studied over the years mostly under axenic conditions, disregarding the natural micro-ecology of host intestine. Using hypoxic culture sediments with oxygen consuming bacteria (OCB niches) we discovered in E. invadens an ancient stem cell system that shows the same basal mechanisms for stemness that exist in highly developed stem cell systems too. The ancient stem cells of E. invadens (AnSC) have all standards of the stem cell definition (self renewing and quiescent cells, glycolytic metabolism, stem cell plasticity, reprogramming and induced totipotency recovery, and both induced and autonomous terminal differentiation) indicating that stem cells were developed by the anaerobe proterozoic LECA-as stages of its life cycle-then diverged into all eukaryotes. The more protist stem cell systems we can dechipher the more we will learn about the ancestral protolineage, its cell line hierarchy and basal mechanism of stemness. We assume that Giardia could be a good model system to expand protist stem cell biology. We found in Giardia literature evidence suggesting self renewal and quiescence, plasticity and other stem cell characteristics. The present study is a reinterpretation of Giardia’s life cycle in the light of current stem cell knowledge. It is hoped this reinterpretation stimulates new developments.

Keywords: LECA, Entamoeba, Giardia, life-cycle, stem cells, stem cell lines, induced and autonomous mechanisms for terminal differentiation

ISSN 2054-717X
Volume 1
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