Table 2 : Statistical comparison of sirolimus dose effect.

	Test	Formulation			ANOVA p-value	Tukey-Kramer p-value
		Empty (A)	0.16 mg/ml (B)	0.4 mg/ml (C)
Heatingmethod	STTI (mm/min)	8.57±4.45	12.60±4.61	11.79±4.65	<0.002	A vs B <0.01 A vs C <0.05
	STTII (mm/min)	3.90±3.08	5.50±2.93	4.95±4.96	Not significant	--
	TBUT (sec)	4.36±1.63	4.72±1.93	3.48±3.37	Not significant	--
Ethanol injection	STT1 (mm/min)	3.86±4.83	9.26±5.55	10.92±6.18	<0.001	A vs C < 0.05
	STT2 (mm/min)	0.60±1.48	2.10±2.97	5.17±4.30	<0.001	A vs B <0.01 A vs C <0.01
	TBUT (sec)	2.80±2.48	1.83±2.13	4.65±2.46	0.001	A vs C <0.05 B vs C <0.01

Data is average±standard deviation
ANOVA: Analysis of variance; STTI: Schirmer test I; STTII: Schirmer test II; TBUT: Tear film break up time