Table 4 : Viral DUBs and their functions.


Viral DUB   Virus   DUB Activity   Function   References

UL48 capsid-associated tegument protein   HCMV   Ubiquitin-specific C-terminal hydrolase (UCH) and Isopeptidase activity for Lys -63 residue   Efficient viral growth at low MOI in cultured cells. Specific mechanism is unknown.   [30]
ORF64- tegument protein   KSHV   Ubiquitin specific cysteine protease (USP) which deubiquitinylates Lys-63   Deubiquitinates RIG-I to inhibit the host’s anti-viral IFN signaling cascade.   [38]
UL36 –inner tegument protein   HSV-1   USP with a lys-48 preferential activity.   Maintains the contact between capsid and tegument. Role as a DUB is unknown.   [29]
BPLF1-viral tegument protein   EBV   USP as well as DUB   Deubiquitinates and inactivates the viral ribonucleotide reductase  subunit RR1.   [34]
    --   --   Inhibits host translesion synthesis by deubiquitinating PCNA.   [35]
BSLF1- component of viral helicase-primase complex   --   DUB   Function as DUB unknown   [32]
BXLF1- viral thymidine kinase   --   DUB   Function as DUB unknown   [33]
EBNA3C- Latent viral antigen   --   DUB   Stabilizes itself to promote B-cell transformation.   [36]
    --   --   Stabilizes Mdm2 to promote p53 degradation.   --
    --   --   Stabilizes Cyclin D1to promote pRb degradation.   [37]

Kumar et al.Virology Discovery  2013 1:5DOI : 10.7243/2052-6202-1-5